Data Analysis and Management Core (DMAC)

2022 Feb 15

Trainee Work-in-Progress: High-Dimensional Inference with De-biased Sparse Canonical Correlation Analysis: Discovering Novel Gene-Protein Networks in Cancer Studies

12:00pm

Location: 

Via Zoom (MEMCARE-SRC members only)

Nathan Huey, Doctoral Student in Biostatistics, Harvard T.H. Chan School of Public Health, MEMCARE-SRC Data Management and Analysis Core (DMAC) will present his work on  High-Dimensional Inference with De-biased Sparse Canonical Correlation Analysis: Discovering Novel Gene-Protein Networks in Cancer Studies. Trainee Work-in-Progress seminars are open to MEMCARE-SRC Center members only.

Nilanjana Laha, Nathan Huey, Brent Coull, and Rajarshi Mukherjee. 9/24/2021. “On Statistical Inference with High Dimensional Sparse CCA.” arXiv.org. Publisher's VersionAbstract
We consider asymptotically exact inference on the leading canonical correlation directions and strengths between two high dimensional vectors under sparsity restrictions. In this regard, our main contribution is the development of a loss function, based on which, one can operationalize a one-step bias-correction on reasonable initial estimators. Our analytic results in this regard are adaptive over suitable structural restrictions of the high dimensional nuisance parameters, which, in this set-up, correspond to the covariance matrices of the variables of interest. We further supplement the theoretical guarantees behind our procedures with extensive numerical studies.

Harvard T.H. Chan School of Public Health

Our Center is based that the Harvard T.H. Chan School of Public Health where the labs of Marc Weisskopf and David Christiani (Project 1), Quan Lu (Project 2), and Tamarra James-Todd (Community Engagement Core) are located in the Department of Environmental Health. The Research Experience and Training Cordination Core (Susan Korrick) and the Administrative (Quan Lu) and Research Translation Core (Trina von Stackelberg) are also based in the Department of Environmental Health. Brent Coull and Xihong Lin's groups (Data Management and Analysis Core) are in the Department of Biostatistics.

Nilanjana Laha

Nilanjana Laha

Data Management and Analysis Core (DMAC) Trainee
Postdoctoral Research Fellow in Biostatistics, Harvard T.H. Chan School of Public Health
Wenying Deng

Wenying Deng

Data Management and Analysis Core (DMAC) Trainee
Doctoral Student in Biostatistics, Harvard T.H. Chan School of Public Health
Nathan Huey

Nathan Huey

Data Management and Analysis Core (DMAC) Trainee
Doctoral Student in Biostatistics, Harvard T.H. Chan School of Public Health
Beau Coker

Beau Coker

Data Management and Analysis Core (DMAC) Trainee
Doctoral Student in Biostatistics, Harvard T.H. Chan School of Public Health

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